在中枢神经系统二级淋巴瘤中对现实世界治疗和结果的前性观察性研究
Stefan Habringer1, Uta M Demel2, Anne-Katrin Fietz3
1Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Berlin Institute of Health at Charité (BIH), Berlin, Germany; German Cancer Consortium (DKTK), Berlin, Germany.
概括
二级中枢神经系统淋巴瘤 (SCNSL) 的预后不好. 这项研究发现,在初始呈现时诊断出SCNSL的生存率更好,自主干细胞移植的高剂量治疗改善了响应性患者的结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 二次性中枢神经系统淋巴瘤 (SCNSL) 由于有限的前性数据和现实世界的证据,提出了重大治疗挑战.
- 由于缺乏可靠的临床研究,SCNSL治疗的进展受到阻碍.
结论:
- 这项研究代表了最大的SCNSL患者前队列,详细介绍了国际治疗格局和结果.
- 在初始呈现 (同步) 时被诊断为SCNSL的患者与后来被诊断的患者相比,表现出更好的预后 (超时).
- 巩固HDT-ASCT是SCNSL患者实现部分反应或更好的潜在有利治疗策略.
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