通过循环RNA介导的KDM3B表达和炎症反应影响KDM3B单核酸多态性辐射疗法毒性
Yin Sun1, Ying Tsai1, Ronald Wood2
1Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
International journal of radiation oncology, biology, physics
|November 26, 2023
概括
在KDM3B中单核酸多态 (SNPs) 影响前列腺癌患者的放射治疗毒性. 较低的KDM3B表达,与尿动频率相关,由SNP调节的非编码RNA引起,导致组织炎症.
科学领域:
- 遗传学和分子生物学
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
背景情况:
- 全基因组关联研究 (GWAS) 已经将特定的单核酸多态 (SNP) 与前列腺癌患者的放射治疗 (RT) 毒性联系起来.
- 在KDM3B中SNP rs17599026与RT后晚期尿动频率增加有关.
研究的目的:
- 阐明KDM3B SNP rs17599026与辐射诱导的尿道毒性之间的机制联系.
- 研究KDM3B表达是如何被遗传变异调节的,以及它在辐射反应中的作用.
主要方法:
- 在人类组织和细胞系中分析KDM3B蛋白表达和SNP等位基因变异.
- 调查KDM3B在辐射毒性中的作用,使用异体Kdm3b删除的小鼠模型.
- 评估炎症和尿功能的分子和生理标志物.
主要成果:
- SNP rs17599026位于循环RNA表达的关键动机中,影响微RNA海绵和KDM3B调节.
- 在小鼠中减少KDM3B表达与膀照射后改变的排尿模式相关.
- 通过基因表达,淋巴细胞透和超声波评估的组织炎症与较低的KDM3B水平有关.
结论:
- KDM3B SNPs通过非编码RNA调节基因表达,影响KDM3B蛋白水平.
- 不同的KDM3B表达通过分子和生理组织炎症导致辐射毒性.
- 这些发现为制定有针对性的策略提供了基础,以减轻前列腺癌幸存者的RT毒性.
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