过度脂肪和女性乳腺癌之间的关系:临床影响和管理
Maria D Hurtado1, Elif Tama1, Stacey D'Andre2
1Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Jacksonville, FL, USA; Precision Medicine for Obesity Program, Mayo Clinic, Rochester, MN, USA.
Critical reviews in oncology/hematology
|November 26, 2023
概括
过度肥胖是影响乳腺癌 (BC) 幸存者的关键因素.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 代谢健康 代谢健康
背景情况:
- 乳腺癌 (BC) 是女性最常见的癌症,幸存者面临心血管疾病增加的死亡率.
- 心血管疾病是BC幸存者中主要的非癌症相关死亡原因.
- 可修改的心脏代谢风险因素,如脂肪过多,显著影响BC缓解,生存率和生活质量.
研究的目的:
- 审查将脂肪组织与乳腺癌联系在一起的证据.
- 检查诊断后体重趋势及其对BC复发和死亡率的影响.
- 为BC幸存者提供关于体重管理的指导,包括减肥干预措施的影响.
主要方法:
- 关于脂肪组织和乳腺癌现有研究的文献综述.
- 对乳腺癌诊断后体重变化数据的分析.
- 对乳腺癌幸存者的减肥干预措施研究的评估.
主要成果:
- 有证据表明,脂肪组织与乳腺癌之间存在显著的联系.
- 诊断后体重增加与BC复发和死亡率的风险增加有关.
- 减肥干预措施对乳腺癌幸存者显示出潜在的益处.
结论:
- 脂肪组织在乳腺癌的结果和幸存者的心血管健康方面发挥着至关重要的作用.
- 体重管理对于改善乳腺癌患者的长期健康和生存至关重要.
- 对BC幸存者进行针对性体重管理策略的进一步研究是有必要的.
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