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Updated: Jun 17, 2026

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
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在人体研究中估计和多醇基物质 (PFAS) 半衰期:系统性审查和元分析

Isabella Rosato1, Tiziano Bonato1, Tony Fletcher2

  • 1Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, Padova, Italy.

Environmental research
|November 26, 2023
PubMed
概括

和多基基物质 (PFAS) 在人类中具有很长的半衰期,从1.48年到8.5年不等. 需要进一步的研究来了解影响PFAS持久性的因素,并改善半衰期估计.

关键词:
半衰期 半衰期 半衰期一个分区模型的模型.在PFAS中,有很多方法.perfluoroalkyl 物质是一种高醇基物质.毒动力学 毒动力学 毒动力学

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...