青素:瘤及其宿主环境中物质的根源
Shobhit P Lall1, Zahraa W Alsafwani1, Surinder K Batra2
1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.
阿斯波林 (ASPN) 是一种富含氨酸的小蛋白质甘氨酸,通过影响关键信号通路,在癌症和骨疾病中发挥双重作用. 准ASPN为恶性瘤和纤维化提供了潜在的治疗策略.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 阿斯波林 (ASPN) 是一种在细胞外基质中发现的I类小型氨酸丰富蛋白质甘氨酸 (SLRP).
- ASPN 具有独特的 N-终端多酸盐 (D-重复) 区域,与其他 SLRP 区别开来,如 德科林 (DCN) 和大甘 (BGN).
- 在ASPN的D-重复中的生殖线多态性与癌症进展和骨关节炎 (OA) 有关.
研究的目的:
- 综合审查ASPN在各种恶性瘤和骨相关疾病中的多方面的作用.
- 更新关于ASPN的结构,变体,突变和癌症相关信号通路的知识.
- 探索针对癌症,纤维化和骨疾病的ASPN治疗潜力.
主要方法:
- 文献综述和对ASPN现有研究的综合.
- 对ASPN参与癌症特征的分析,如扩散,转移和亡抵抗.
- 检查ASPN对信号通路的调节,包括TGFβ,Wnt/β-catenin和EGFR.
主要成果:
- ASPN涉及促进癌细胞的入侵,增殖和通过上皮细胞转移到介质细胞转移 (EMT) 的迁移.
- ASPN 影响癌症 - 巨交叉声,免疫细胞功能和免疫抑制.
- 在癌症和骨疾病中,ASPN调节关键信号通路 (例如TGFβ,Wnt/β-catenin,EGFR).
结论:
- 在癌症和骨疾病中,ASPN表现出双重作用,根据上下文,它既起促进作用,也可能起抑制作用.
- 了解ASPN复杂的机制为新的治疗干预提供了机会.
- 针对ASPN是一个有希望的策略来治疗癌症,纤维化和其他与骨相关的病理.
更多相关视频
09:42Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions
Published on: May 16, 2020
09:52A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
相关概念视频
The Tumor Microenvironment
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Abnormal Proliferation
Mitogens and the Cell Cycle
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
