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帕金森病中的calprotectin:预期和奉献

Hayder M Al-Kuraishy¹, Ali I Al-Gareeb¹, Ayah Talal Zaidalkiani²

¹Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq.

Ageing research reviews

|November 26, 2023

概括

帕金森病 (PD) 患者的高便calprotectin水平表明肠道失调和肠道炎症. 这种生物标志物可以预测肠道屏障损伤和神经炎症,可能会在几十年之前出现运动症状.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
微生物学微生物学

背景情况:

帕金森病 (PD) 涉及多巴胺基神经元退化,导致运动和非运动症状.
非运动性症状,如便秘和PD药物影响肠道微生物群,可能导致失能.
肠道功能失调可以增加肠道的透性,导致系统性炎症和神经炎症.

研究的目的:

审查肠道屏障损伤和PD神经病理学中的失生症的作用.
探索calprotectin水平如何反映PD的肠道屏障损伤.
突出便calprotectin作为PD的潜在诊断和预后生物标志物.

主要方法:

临床前和临床研究的文献综述.
分析肠道微生物群,肠道屏障功能和PD之间的关系.
检查calprotectin作为肠道炎症和肠道屏障完整性的指标.

主要成果:

在PD患者中,高的calprotectin水平与肠道失调和肠道炎症相关.
肠道屏障损伤和失生症可能会在PD出现运动症状之前.
在PD的背景下,calprotectin作为肠道屏障损伤和炎症的标记物.

结论:

便中的calprotectin是PD中肠道失调和肠道炎症的重要指标.
早期发现便calprotectin的增加可能标志着肠道失调或障碍障碍损伤之前的运动症状.
便calprotectin显示为帕金森病的诊断和预后生物标志物具有前途,需要进一步研究.

关键词:

在 Calprotectin 中使用.神经炎症是一种神经炎症.帕金森病是帕金森氏症的一种疾病.

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