伦瓦提尼布加布利祖马布组合治疗晚期或复发性子宫内膜癌:一个单中心的回顾性分析
Mikako Tochigi1, Shogo Shigeta1, Muneaki Shimada1,2
1Department of Obstetrics and Gynecology, Tohoku University School of Medicine.
The Tohoku journal of experimental medicine
|November 26, 2023
概括
伦瓦提尼布加上布罗利祖马布在日本的晚期子宫内膜癌中显示出有效性. 然而,小心对甲状腺功能低下和高血压等不良事件进行管理至关重要,通常需要调整剂量.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 伦瓦提尼布加布罗利祖马布是治疗晚期或复发性子宫内膜癌的治疗选择.
- 日本人口独特的遗传背景可能会影响治疗结果.
- 本研究评估了这种组合在日本队列中的疗效和安全性.
研究的目的:
- 评估伦瓦提尼布加布罗利祖马布在日本患有晚期或复发性子宫内膜癌的患者的治疗疗效.
- 评估与这种联合治疗相关的安全性和不良事件.
- 探索伦瓦提尼布剂量强度与无进展生存时间之间的关系.
主要方法:
- 东北大学医院15名患者的临床记录的回顾性分析.
- 评估最佳整体反应,疾病控制率和生存时间.
- 分析不良事件,剂量降低和停止治疗的原因.
主要成果:
- 最好的整体应答率为40.0%,疾病控制率为73.3%.
- 无进展生存时间的中位数为258天; 3名患者的治疗正在进行中.
- 常见的不良事件包括甲状腺功能低下 (90%) 和高血压 (83.3%);13名患者需要降低剂量.
结论:
- 伦瓦提尼布加上潘布罗利祖马布在这个日本队列中显示出短期的疗效.
- 在不影响疗效的情况下,可能可以进行个性化的伦瓦提尼布剂量优化.
- 密切监测和管理不良事件对于成功治疗至关重要.
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