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针对乳腺癌和胃肠道癌症中的HER2异质性

Carmine Valenza¹, Lorenzo Guidi¹, Elena Battaiotto¹

¹Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Trends in cancer

|November 26, 2023

概括

人类表皮生长因子受体2 (HER2) 表达在瘤内和随着时间的推移而变化,影响治疗的有效性. 鉴定这种HER2异质性对于指导治疗HER2过度表达癌症至关重要.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症生物标志物癌症生物标志物

背景情况:

人类表皮生长因子受体2 (HER2) 在约20%的乳腺癌和胃癌以及3%的结直肠癌中过度表达.
针对HER2的疗法对患有HER2过度表达瘤的患者有效.
HER2的表达可以在瘤内部 (瘤内部异质性),不同瘤部位之间 (瘤间异质性),以及在治疗期间 (时间异质性) 随着时间的推移而变化.

研究的目的:

突出在固体瘤中定义和表征HER2异质性的挑战.
强调空间和时间 HER2 异质性对治疗反应和耐药性的影响.
要强调需要HER2异质性表征作为指导治疗调节的预测生物标志物.

主要方法:

对固体瘤中HER2表达异质性的现有文献的综述.
分析不同类型癌症中HER2异质性的流行率和预测作用.
讨论实施HER2异质性作为可再生生物标志物的挑战.

主要成果:

HER2异质性是HER2过度表达的固体瘤中常见的现象.
在HER2表达的空间和时间变化可以影响HER2导向药物的疗效.
在不同类型的瘤中,HER2异质性的预测值有所不同.

结论:

对于准确的诊断和治疗计划,HER2异质性带来了重大挑战.
描述HER2异质性对于优化治疗策略至关重要.
实施可重复的方法来评估HER2异质性可以通过指导治疗决策来改善患者的治疗结果.

关键词:

HER2异质性 HER2的异质性乳腺癌乳腺癌乳腺癌结肠直肠癌是什么意思胃癌胃癌是一种胃癌.人类表皮生长因子受体2

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