COVID-19感染对工作记忆的影响:系统性审查
Rui Cui1, BeiYao Gao2, RuiDong Ge2
1College of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
Current medical research and opinion
|November 27, 2023
概括
COVID-19显著影响工作记忆,感染后长时间持续下去. 本系统性审查强调了SARS-CoV-2感染后认知缺陷的流行率和持续时间.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 认知科学 认知科学
背景情况:
- 导致COVID-19的严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染与认知功能障碍有关.
- 在感染后报告工作记忆障碍,执行功能障碍和注意力降低.
研究的目的:
- 系统地审查COVID-19患者工作记忆障碍的发生率.
- 为了探索COVID-19急性 (<3个月) 和慢性 (>6个月) 阶段的并发症状.
主要方法:
- 系统审查的 MEDLINE,PubMed,Cochrane EMBASE 和科学网络.
- 包括PCR或血清学确认的SARS-CoV-2感染和没有先前认知障碍的观察性研究.
- 在PROSPERO注册的协议 (CRD42023413454).
主要成果:
- 包括16项涉及502篇文章的研究.
- 工作记忆障碍在急性阶段影响22.5-55%,慢性阶段影响6.2-10%.
- 与年龄,感染后的时间和感染严重程度相关的损伤;神经炎症和病毒神经侵入性是相关的机制.
结论:
- COVID-19可能导致持续的工作记忆力下降和神经症状.
- 需要进一步的研究来确定与COVID-19后工作记忆受损相关的特定结构和功能大脑变化.
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