结合梅莉莎花和帕纳克斯人参的记忆和认知增强效应
Hira Afshan1, Humera Khatoon2, Aisha Aziz2
1Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan/Department of Pharmacy Practice, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences
|November 27, 2023
概括
这项研究发现,结合梅丽莎和帕纳克斯人参提取物,可显著改善大鼠的认知功能和记忆力. 这些草本提取物显示出增强大脑健康和认知表现的潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
背景情况:
- 认知障碍是一个日益关注的问题,需要对自然化合物的研究,以寻找潜在的治疗益处.
- 梅丽莎官员植物 (香) 和帕纳克斯人参是传统的草药,据报道具有增强认知能力的特性.
- 研究这些草药的协同作用可能为改善记忆和认知提供新的策略.
研究的目的:
- 为了评估梅丽莎官员植物和帕纳克斯人参提取物在白色老鼠模型中对认知行为的联合作用.
- 为了确定不同剂量的联合提取物在改善学习和记忆方面的有效性.
- 探索其体外作用机制,特别是乙 - 胆 - 酶抑制.
主要方法:
- 从2022年6月到2023年3月进行的前性实验研究.
- 使用行为测试评估认知功能:被动回避测试,莫里斯水迷宫和8臂辐射迷宫.
- 进行了体外分析,以测量联合提取物对乙胆雌激酶的抑制.
主要成果:
- 两种剂量 (100/100mg/kg和200/200mg/kg) 的联合提取物在所有行为测试中显著改善了学习和记忆,与对照组和斯科波胺组相比 (p<0.001).
- 接受治疗的组在被动回避测试中表现出更长的延迟时间,并在莫里斯水迷宫中减少了逃脱延迟时间.
- 实验室内研究显示,M. officinalis和P. ginseng组合的36.40%的乙胆酶抑制.
结论:
- 结合梅丽莎花和帕纳克斯人参提取物,证明了在增强认知功能和记忆方面具有显著的潜力.
- 这些发现支持使用这些草本提取物作为改善认知表现的治疗策略.
- 需要进一步的研究来阐明完整的药理学特征和临床应用.
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