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在研究和实践中进行和实施个性化试验

Richard L Kravitz^1,2, Naihua Duan^3,4

¹Department of Internal Medicine, University of California, Davis.

Harvard data science review

|November 27, 2023

概括

个性化试验,或N-of-1试验,评估个体治疗的有效性,但面临的采用障碍. 克服设计和实施的挑战是它们在医学中更广泛使用的关键.

科学领域:

临床试验临床试验
医学研究方法学医学研究方法学
个性化医疗是个性化的医疗.

背景情况:

随机对照试验 (RCT) 是证据开发的标准,重点是平均治疗效果.
个性化试验 (N-of-1试验) 评估在单个个体内的比较治疗有效性.
尽管使用了40多年,但N-of-1试验在医学上得到了有限的采用.

研究的目的:

审查个性化试验的基本要素.
确定阻碍广泛采用N-of-1试验的障碍.
探索改善个性化试验的部署性和实用性的策略.

主要方法:

对个性化 (N-of-1) 试验设计和实施的现有文献的审查.
分析实际挑战,包括饮食调节的灵活性,失明和洗期.
讨论组织,临床医生和患者层面的障碍.

主要成果:

有有限的证据表明,个性化试验有所改善.
实际设计和实施问题,而不是有效性证明,是主要的障碍.
组织和个人层面的挑战阻碍了广泛采用.

结论:

个性化试验提供了一种有价值的方法来评估个体治疗的有效性.
解决实际的设计,实施和后勤挑战对于更广泛的采用至关重要.
新兴技术可能会克服当前的障碍,增强未来的个性化试验研究.

关键词:

这是一种令人眼花乱的失明.治疗效应 (HTE) 的异质性个性化治疗效应 (ITE)个性化试验个性化试验随机对照试验 (RCT) 是一种随机对照试验.在没有洗的情况下.

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