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鼠标菌株之间的热中性区范围的差异:对翻译研究的潜在影响

Andrzej K Gębczyński¹, Julita Sadowska¹, Marek Konarzewski¹

¹Faculty of Biology, University of Białystok, Białystok, Poland.

American journal of physiology. Regulatory, integrative and comparative physiology

|November 27, 2023

概括

环境温度显著影响小鼠代谢研究. 了解下临界温度 (LCT) 对于在翻译研究中准确计算每日能量消耗 (DEE) 与基础代谢率 (BMR) 的比率至关重要.

科学领域:

代谢研究的研究.
动物模型动物模型
热调节热调节热调节

背景情况:

实验室小鼠对于人类新陈代谢研究至关重要.
准确的人类能量需要每日能源消耗 (DEE) 与基础代谢率 (BMR) 的比率为1.7-1.8.8.
DEE/BMR比率受到相对于热中性区域的环境温度的影响.

研究的目的:

分析环境温度对小鼠DEE/BMR比率偏差的影响.
研究低临界温度 (LCT) 在翻译研究中的作用.
评估小鼠菌株间的LCT变异如何影响代谢研究.

主要方法:

使用的小鼠选择了高和低的BMR.
分析了关于小鼠菌株和LCT的现有文献数据.
检查了环境温度,LCT和DEE/BMR比率之间的关系.

主要成果:

在高BMR和低BMR小鼠线之间,估计的LCT差异超过7°C.
在常见的小鼠菌株中,LCT范围跨越23°C至33°C.
低于LCT的DEE/BMR比率增加了0.172°C^-1,根据菌株而有所不同.

结论:

温度调节的能量成本在不同小鼠菌株之间有很大差异.
在LCT中的差异可以在转化代谢研究中引入实质性的偏差.
考虑到特定小鼠菌株的LCT对于强大的翻译研究设计至关重要.

关键词:

基本代谢率基本代谢率实验室小鼠实验室小鼠身体活动水平.热中性区域是一个热中性区域.翻译研究是翻译研究.

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