与炎症相关的母体累积暴露与儿童注意力缺陷/多动障碍之间的关联:一个队列研究
Timothy C Nielsen1, Natasha Nassar1, Antonia W Shand1,2
1Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Paediatric and perinatal epidemiology
|November 27, 2023
概括
孕产妇对炎症的暴露累积增加了儿童多动症的风险. 多次暴露会放大这种风险,突出通过可修改因素预防的潜力.
科学领域:
- 神经发育障碍 神经发育障碍
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于母亲的炎症暴露和后代神经发育的有限人类数据.
- 临床前研究表明有协同效应.
研究的目的:
- 检查母亲与炎症相关的暴露和儿童ADHD之间的累积关联.
- 调查这些暴露之间的潜在相互作用.
主要方法:
- 澳大利亚新南威尔士州基于人口的队列研究 (n=908,770).
- 确定了七种母体暴露 (自身免疫性疾病,喘,感染,情绪障碍,吸烟,高血压,糖尿病).
- 通过使用考克斯回归的兴奋剂处方记录评估儿童ADHD.
主要成果:
- 每个母亲的暴露独立地与ADHD风险增加有关.
- 风险随着累积暴露而升级: 1 (HR 1.59), 2 (HR 2.25), 3+ (HR 3.28). 风险随着累积暴露而升级: 1 (HR 1.59), 2 (HR 2.25), 3+ (HR 3.28).
- 在吸烟和感染之间观察到协同作用;喘,感染,情绪障碍和吸烟的风险最高 (HR 6.12).
结论:
- 累积的母体炎症暴露显著提高了儿童多动症多动症的风险.
- 这些暴露是可能可以预防或修改的.
- 未来的研究应该探索生物标志物和基因环境相互作用.
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