神经性厌食症中的心脏整体感应:一个休息状态的心跳唤起的潜在研究研究
Susanne Cambi1, Marco Solcà1, Nadia Micali2,3
1Department of Psychiatry, Geneva University Hospital, Geneva, Switzerland.
概括
患有神经厌食症 (AN) 的人表现出心脏整体感受受障碍,其证据是身体意识至关重要的区域的大脑活动发生变化. 这种神经差异在疾病早期观察到,表明以整体感知为重点的疗法可能有助于恢复.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 神经性厌食症 (AN) 与整体感知缺陷有关,影响身体意识,饥饿和情绪处理.
- 以前的研究表明,整体感知功能障碍与AN的核心症状之间存在联系.
研究的目的:
- 客观地评估使用高密度电脑摄影 (hdEEG) 的AN个体的心脏整体感应.
- 调查AN中心脏整体感受改变的神经相关物.
主要方法:
- 用休息状态EEG和ECG记录心跳唤起的潜能 (HEPs) 在22名AN和19名健康对照 (HC) 个体中.
- 用波形,地形和源影像分析来比较心跳的皮质表示.
主要成果:
- 在AN和HC组之间发现了心跳皮质处理的显著差异 (332-348 ms后R峰).
- 源影像显示,在患有AN的人群中,右侧大脑区域的激活减少,包括前带膜和轨道前皮层.
结论:
- 这项研究是第一个使用hdEEG在AN中定位HEP源的研究,证明了改变的感官处理.
- 这些发现表明,对AN的整体受体缺陷可能不仅仅是长期饥饿的结果.
- 在治疗干预中准整体受体可能有利于AN恢复.
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