在治疗类风湿性关节炎方面,etanercept原始剂和生物类似剂的比较有效性:对成本节约的影响
Claire T Deakin1,2,3, Geoffrey O Littlejohn1,4, Hedley Griffiths1,5
1OPAL Rheumatology Ltd, Sydney, New South Wales, Australia.
Internal medicine journal
|November 27, 2023
概括
埃坦尼塞普特 (ETN) 原始剂和生物类似剂SB4在类风湿性关节炎患者中显示出类似的治疗持久性. 引入ETN生物仿制剂为澳大利亚政府节省了大量成本.
科学领域:
- 类风湿病学 类风湿病学
- 药物经济学 药物经济学
- 现实世界的证据.
背景情况:
- 类风湿性关节炎 (RA) 管理通常涉及生物疗法,如乙太 (ETN).
- 原始生物制品与生物类似药的比较有效性和成本效益对医疗保健系统至关重要.
研究的目的:
- 为了比较埃坦塞普特原始剂 (恩布雷尔) 和埃坦塞普特生物类似剂SB4 (Brenzys) 的有效性,作为一线RA治疗.
- 评估在澳大利亚使用ETN生物类似药的潜在成本节约.
主要方法:
- 分析了来自"优化患者结果"的现实世界数据在瘤学澳大利亚数据集中的分析.
- 包括成人RA患者启动ETN发起剂或SB4生物类似药作为他们的第一个生物/向合成DMARD.
- 基于澳大利亚定价政策的治疗持续性和成本节约估计的生存分析.
主要成果:
- 倾向性得分匹配和治疗权重的逆概率确保了原始体 (n=209) 和生物类似体 (n=141) 组之间的可比基线特征.
- 治疗中断50%的中位时间是相似的:19.4个月用于原始药和22.4个月用于生物类似药 (P=0.95).
- 引入ETN生物类药物导致研究患者队列的预计年度成本节省超过950万澳元.
结论:
- 在澳大利亚的RA患者中,Etanercept原始剂和生物类似剂SB4显示了可比的治疗持久性.
- 列入ETN生物类似药的清单显著降低了所有ETN品牌的成本.
- 由于采用ETN生物类似剂,澳大利亚政府实现了大量的成本节约.
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