来自的气味受体 ортолог显示了对cis-jasmone的保留反应
Xiao-Qing Hou1, Zhongqiang Jia1, Dan-Dan Zhang2
1Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Synthetic Biology Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong Province, China.
Insect science
|November 27, 2023
概括
对于像cis-jasmone这样的生态重要化合物,的嗅觉受体 (ORs) 是高度保存的. 在物种中这种功能性和遗传性保存突显了它们在昆虫化学交流中的重要性.
科学领域:
- * 昆虫嗅觉系统的演变和功能.
- * 类动物中化学感应的分子基础.
背景情况:
- * 昆虫的嗅觉受体 (ORs) 通常通过出生和死亡模式进化,从而产生特定物种的谱.
- * ORs 在物种之间表现出不寻常的遗传保护,形成不同的分类.
- * 通过保存的ORs可以识别生态重要化合物.
研究的目的:
- * 测试该假设,即关键生态化合物的 ORs 功能性保存.
- * 为了研究BmorOR56的ortologues的保存,这是cis-jasmone的受体.
主要方法:
- *使用Xenopus卵细胞记录测试cis-jasmone反应的功能测试.
- *dN/dS分析以评估进化选择压力.
- * 分子对接用于比较连接体结合口袋结构.
主要成果:
- *所有经过测试的BmorOR56 ортолог都仅对cis-jasmone产生反应,显示了保留的特异性.
- *dN/dS分析表明,在这个OR组中存在强烈的净化选择.
- * 分子对接揭示了在BmorOR56的ortologues中类似的连接体结合口袋.
结论:
- * 生态重要化合物的气味受体在 (Heterocera) 中高度保存.
- * BmorOR56 正解组是功能和结构保护的典范.
- *这种保护可能反映了特定化学线索对虫生态和行为的重要性.
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