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呼出的氧化仅在过敏敏感的儿童中是喘相关的生物标志物
Rikke Bjersand Sunde1,2, Jonathan Thorsen1, Frederikke Skov1,2
1COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
概括
在患有喘的儿童中,呼出的氧化 (FeNO) 分数升高. FeNO仅在过敏敏感的儿童中是有效的喘生物标志物,影响了临床指南.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 生物标志物研究 生物标志物研究
背景情况:
- 呼出的氧化 (FeNO) 分数是儿童喘的诊断工具.
- 过敏敏感性对儿童FeNO水平的影响尚不清楚.
- 这项研究调查了喘,过敏敏感化和童年FeNO之间的相互作用.
研究的目的:
- 确定喘和过敏敏感性如何影响整个儿童时期的FeNO水平.
- 评估FeNO作为喘生物标志物的有效性,与过敏敏感性相关.
- 为临床指南提供关于FeNO在儿科喘管理中的使用的见解.
主要方法:
- 在COPSAC2000出生队列中分析了5-18岁的FeNO水平 (n=411).
- 重复测量混合模型调整了诸如妊娠年龄,性别,感染和环境暴露等混因素.
- 在COPSAC2010出生队列 (n=700) 中复制发现.
主要成果:
- 喘和空气过敏原敏感性都与更高的FeNO水平独立相关.
- 喘在敏感儿童中增加了FeNO,但在非敏感儿童中降低了FeNO (p-相互作用<.0001).
- 与喘相关的特征 (乙素,IgE,支气管扩展剂反应,支气管过敏反应) 仅在敏感儿童中与FeNO相关.
结论:
- 儿童的FeNO水平受到喘和过敏敏感性的影响.
- 只有当同时存在空气过敏原敏感性时,FeNO才是儿童中可靠的喘生物标志物.
- 这些发现需要重新评估FeNO在儿科喘指南中的临床实用性.
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