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Updated: Jul 10, 2025

Transcriptome-Wide Profiling of Protein-RNA Interactions by Cross-Linking and Immunoprecipitation Mediated by FLAG-Biotin Tandem Purification
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Transcriptome-Wide Profiling of Protein-RNA Interactions by Cross-Linking and Immunoprecipitation Mediated by FLAG-Biotin Tandem Purification

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对8-Oxoguanosine敏感RNA-蛋白相互作用的化学蛋白质分析

Jennifer Villers1, Eliana McCann Smith1, Amanda N DeLiberto1

  • 1Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

Biochemistry
|November 27, 2023
PubMed
概括

氧化应激会在RNA中产生8-oxoguanine (8OG),从而改变RNA-蛋白相互作用. 这项研究确定了与8OG修饰RNA结合或被它排斥的蛋白质,揭示了对细胞RNA处理的影响.

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Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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