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中度和晚期早产婴儿肠道微生物组的可逆异常:来自随机对照试验的结果
Raakel Luoto1,2, Anna Pärtty1,2, Josef K Vogt3
1Department of Pediatrics and Adolescent medicine, Turku University Hospital, Turku, Finland.
Gut microbes
|November 27, 2023
概括
这项研究表明,益生菌和益生菌可以帮助早产婴儿发展健康的肠道微生物群,类似于满期婴儿. 这些干预措施可以在关键的发育窗口中逆转有害变化.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 早产婴儿的肠道微生物群与满期婴儿有很大不同,影响健康结果.
- 了解早产婴儿肠道微生物组的纵向发育和调节至关重要.
研究的目的:
- 为了研究中度和晚期早产婴儿的肠道微生物组合和功能.
- 评估益生菌和益生菌干预措施对早产婴儿肠道微生物群的影响.
- 为了比较早产婴儿的肠道微生物组与健康的全产婴儿的参考组.
主要方法:
- 在43名早产婴儿中,从出生到12个月的肠道微生物组的纵向元基因组测序.
- 益生菌 (Lacticaseibacillus rhamnosus GG) 和益生菌干预与安慰剂的随机对照试验.
- 包括9名健康的,满期的,通过阴道分娩的,母乳养的婴儿作为参考组.
主要成果:
- 在第一个月,早产和满期婴儿表现出分类学上的差异,但功能潜力相似.
- 过早出生婴儿的肠道微生物组在6个月后汇聚到满期婴儿的肠道微生物组.
- 益生菌和益生菌治疗加速了早产婴儿中Bifidobacteria主导的肠道微生物组的发展.
结论:
- 特定的益生菌和益生菌可以减轻早产婴儿肠道微生物组的有害变化.
- 干预措施可以在脆弱的低弹性时期逆转一种促炎性肠道微生物群.
- 这些发现支持微生物组调制促进早产婴儿免疫和代谢成熟的潜力.
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