早期血液中的乳酸盐作为心血管崩的生物标志物在实验性败血症中
Thander Jacson Nunes Calente1, Lucas Braga Albino1, Junior Garcia de Oliveira1
1Department of Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Shock (Augusta, Ga.)
|November 27, 2023
概括
在败血症中早期的乳酸测量可以预测大鼠的心血管崩. 乳酸水平为2.45 mmol/L,可以准确地识别血症模型中的血管性反应,从而改进了实验设计.
科学领域:
- 败血症的研究研究.
- 心血管生理学心血管生理学
- 发现生物标志物的发现.
背景情况:
- 结和刺穿 (CLP) 是一种标准的败血症模型.
- 临床肺炎表现出很高的变化,30%的动物缺乏心血管变化.
- 需要早期的生物标志物来预测毒症模型中的心血管崩.
研究的目的:
- 为了确定早期的乳糖增加是否预测低血压和血管缩器低反应性,在老鼠败血症模型中.
- 建立乳酸酸作为预测性生物标志物用于败血症引起的心血管功能障碍.
主要方法:
- 雄性和雌性Wistar老鼠接受了CLP或假手术.
- 尾部血液中的乳酸盐水平在手术后6,12和24小时被测量.
- 评估了血液动力学,炎症和生化参数;使用了接收器操作特征 (ROC) 曲线分析.
主要成果:
- 患有CLP的老鼠出现了低血压,血管缩剂低反应性,炎症和器官功能障碍标志物.
- 乳酸值为2.45 mmol/L,可以在患有血管的老鼠中区分,准确度为84% (AUC:0.84).
- 预测血管的灵敏度为75%,真负率为81%.
结论:
- 早期乳酸盐测量是败血症研究中的一个有价值的生物标志物.
- 乳酸水平可以在CLP模型中区分血管和非血管的老鼠.
- 这种生物标志物可以改进败血症实验模型并改善临床翻译.
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