未来的试点研究评估维生素D3的加载剂量在严重疾病的儿童维生素D缺乏
Elizabeth W Covington1, Shaneese L Jasper-Trotter1, Robert D Arnold1
1Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA.
Fundamental & clinical pharmacology
|November 27, 2023
概括
高剂量的维生素D3补充剂显著提高了25-氧维生素D3水平在重症儿童. 这种干预迅速纠正了儿科重症监护病房患者的维生素D缺乏.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D缺乏症在重症儿童中很普遍.
- 这种人群的最佳维生素D补充策略仍然不清楚.
- 这项研究解决了需要有效的补充协议的需求.
研究的目的:
- 评估高剂量维生素D3对25-氧维生素D3 (25[OH]D3) 水平的影响.
- 在儿科重症监护室 (PICU) 患者中评估特定补充剂疗程的疗效.
- 为了确定单次高剂量是否可以纠正基线维生素D缺乏症.
主要方法:
- 在儿科重症监护病房进行前性试点研究.
- 包括患者 (<18岁) 的基线25[OH]D<30 ng/ml.
- 服用一次口服或胃用维生素D3剂量 (10,000 IU/kg,最大. 400万 IU) 的时间.
主要成果:
- 包括11名患有维生素D缺乏症的儿科患者.
- 平均25(OH) D3水平在12小时内显著增加,从21.6到46.7 ng/ml (P < 0.001).
- 91%的患者在补充后达到> 30 ng/ml的水平;没有报告的不良反应.
结论:
- 高剂量的维生素D3 (1万IU/kg) 能有效且快速地提高严重病症儿童的25~OH) D3水平.
- 这种补充策略在PICU环境中有望纠正维生素D缺乏.
- 进一步的研究可能会探索长期的结果和最佳的剂量间隔.
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