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A Cardiac Microphysiological System for Studying Ca2+ Propagation via Non-genetic Optical Stimulation
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用于精准医学的患者衍生微生理学系统.

Jihoon Ko1, Jiyoung Song2, Nakwon Choi2,3,4

  • 1Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, 13120, Republic of Korea.

Advanced healthcare materials
|November 27, 2023
PubMed
概括

患者衍生微生理系统 (P-MPS) 为精准医学提供了对个体患者特征的洞察力. 这些系统将患者样本集成到微流体设备中,以实现更好的治疗策略.

关键词:
微生理系统的微生理系统.患者衍生的患者衍生.在生理学上具有重要意义的.精准医学是一门精准医学.

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科学领域:

  • 生物医学工程 生物医学工程
  • 翻译医学是一种翻译医学.
  • 再生医学是一种再生医学.

背景情况:

  • 患者衍生微生理系统 (P-MPS) 对于推进精准医学至关重要.
  • 他们将患者衍生细胞,有机体和干细胞整合到微生理系统 (MPS) 中.
  • P-MPS弥合了传统的体外模型和临床结果之间的差距.

研究的目的:

  • 审查P-MPS在精准医学中的发展和意义.
  • 为P-MPS开发提供有关工程方法的指导.
  • 探索P-MPS的临床影响和结果.

主要方法:

  • 将来自患者的样本 (细胞,有机体,iPSC) 集成到MPS.
  • 开发用于P-MPS的微流体设备.
  • 高含量分析用于P-MPS实验的应用.

主要成果:

  • P-MPS 能够实现高生物相关性和高通量实验.
  • 从不同患者获得的样本中获得的生理学相关数据.
  • 证明了临床相关性和对个体患者特征的洞察力.

结论:

  • P-MPS是了解个体患者特征的重要工具.
  • 它们有助于制定个性化治疗策略.
  • 在临床应用中,P-MPS代表了非临床评估的重大进步.