补充维生素C可以缓解由慢性压力引起的高皮质素血症
Narine Beglaryan1,2, Gagik Hakobyan3, Eduard Nazaretyan4
1Astghik Medical Center, Yerevan, Armenia.
概括
亚酸 (AA) 补充剂有效降低了功能性高皮质素贫血症妇女的高血皮质醇和脱氨硫酸 (DHEA-S) 水平. 这项研究表明AA作为一种潜在的治疗方法来使受影响个体的激素水平正常化.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 功能性高皮质醇血症的特征是皮质醇和脱氨硫酸 (DHEA-S) 水平升高,通常与慢性压力有关.
- 目前对功能性高皮质血的治疗选择可能存在局限性,需要探索替代干预措施.
研究的目的:
- 研究阿斯科布酸 (AA) 补充剂在降低有功能性高皮质素血患者的血皮质醇和DHEA-S水平方面的疗效.
- 根据初始激素升高,评估AA对不同患者亚组激素水平的影响.
主要方法:
- 一项为期2个月的研究,涉及69名患有皮质醇和/或DHEA-S升高的女性患者.
- 根据荷尔蒙水平,患者被分为三组,随机分配每天服用1000毫克口服 Askorbic 酸 (AA) 或不进行干预.
- 在2个月的干预期之前和之后测量了激素水平 (皮质醇和DHEA-S).
主要成果:
- 阿斯科布酸补充剂导致治疗小组中血皮质醇和DHEA-S水平升高的显著降低.
- 在I组,皮质醇水平显著下降 (p=0.000065);在II组,皮质醇 (p=0.005) 和DHEA-S (p=0.0007) 水平显著下降.
- 接受AA的III组患者的DHEA-S水平显著降低 (p=0.003),而未接受治疗的亚组患者显示激素变化微不足道.
结论:
- 阿斯科布酸 (AA) 补充剂有效降低功能性高皮质醇血和DHEA-S水平的女性患者的血皮质醇和DHEA-S水平.
- AA治疗可以帮助在皮质醇和/或DHEA-S升高的个体中使激素水平正常化,这表明其具有治疗潜力.
- 这项研究支持AA作为一种可行的选择,用于管理功能性高皮质血和相关的荷尔蒙失衡.
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