在孕期暴露于阿片类药物后,母亲的护理行为和生理学适度的后代结果
Abigail M Myers1, Scott E Bowen1,2, Susanne Brummelte1,2
1Department of Psychology, Wayne State University, Detroit, Michigan, USA.
Developmental psychobiology
|November 27, 2023
概括
治疗阿片类药物使用障碍 (MOUD) 的药物,如布普伦诺芬 (BUP),可以在怀孕期间暴露胎儿. 这次审查审查了BUP的BUP.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物流行病增加了产前阿片类药物暴露.
- 治疗阿片类药物使用障碍 (MOUD) 的药物,如布普伦诺芬 (BUP),用于治疗依赖阿片类药物的孕妇.
- 在子宫内BUP暴露对胎儿神经发育的长期影响尚不清楚.
研究的目的:
- 审查和比较产前阿片类药物暴露后后代的结果与减少母亲护理.
- 调查潜在的共同机制,潜在的不良结果.
- 探索孕期BUP暴露的影响是由于直接暴露于胎儿,改变母亲的护理,还是两者兼而有之.
主要方法:
- 文献综述和临床前和临床研究的综合.
- 比较产前阿片类药物暴露后代的结果和报告减少母亲护理的研究.
- 在妊娠期阿片类药物暴露研究中分析母亲的护理行为.
主要成果:
- 在产前接触阿片类药物后观察到不良后代结果.
- 众所周知,减少母亲的照顾会对后代的发展产生负面影响.
- 许多研究未能报告母亲的护理,这复杂化了对阿片类药物暴露效应的解释.
结论:
- 评估妊娠期阿片类药物暴露的影响需要考虑母婴二极管和母婴护理.
- 不良结果可能是由于直接的阿片类药物影响,产妇护理缺陷或组合而产生的.
- 需要改进的临床前模型,以便对改善阿片类药物依赖母亲的临床结果进行更可翻译的研究.
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