在COVID-19诊断和严重程度评估中比较血和皮肤印记代谢资料
Jeany Delafiori1, Rinaldo Focaccia Siciliano2,3, Arthur Noin de Oliveira1
1Innovare Biomarkers Laboratory, Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, Brazil - Rua Cinco de Junho, 350 - 13083-970 - Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
皮肤印记为COVID-19诊断和严重程度评估提供了一种非侵入性方法. 这项研究发现,皮肤印记有效识别住院患者,补充了血代谢学,以了解疾病.
科学领域:
- * 代谢学和脂质学
- * 传染病诊断 传染病诊断
- * 皮肤病学和非侵入性采样
背景情况:
- *COVID-19诊断和了解SARS-CoV-2变种仍然至关重要.
- * 皮肤表现在COVID-19中很常见,但其潜在的机制和生物标志物尚未得到充分理解.
- * 需要非侵入性采样方法来监测和诊断疾病.
研究的目的:
- * 通过使用非向代谢学来研究皮肤印记和血样本对COVID-19诊断的有用性.
- * 确定潜在的生物标志物,以区分COVID-19患者和对照者,并评估疾病的严重程度.
- * 评估皮肤印记作为COVID-19的非侵入性采样策略.
主要方法:
- *涉及101名参与者 (64名COVID-19阳性,37名对照) 的横截面研究.
- *使用板和血样本采集的非侵入性皮肤印记采集.
- *通过高分辨率质谱学进行非向性脂管学/代谢学分析.
主要成果:
- *从皮肤印记和血中鉴定出558个分子离子,主要是脂质.
- *与皮肤印记 (F1得分84.3%) 相比,血样本对COVID-19的诊断准确性更高 (F1得分91.9%).
- * 皮肤印记在评估疾病严重程度方面表现出色 (F1得分为93.5%),确定了胺和胺作为住院患者的关键生物标志物.
结论:
- *皮肤印记在疾病代谢学中作为血的宝贵补充.
- *已确定的生物标志物,包括脂肪酸胺基,在免疫调节和代谢障碍中起作用.
- *皮肤印记显示出作为COVID-19查和严重性评估的非侵入性采样方法的巨大潜力.
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