身体质量,神经激素压力处理和疾病活动在患有多发性硬化症的瘦到肥胖人群中
Lil Meyer-Arndt1,2,3,4,5, Jelena Brasanac1,2,3,4,6, Stefanie Gamradt6
1Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin, Berlin, Germany.
Journal of neurology
|November 27, 2023
概括
多发性硬化症 (MS) 中的肥胖与疾病活性增加有关. 较高的体重指数 (BMI) 与神经应激处理和免疫细胞功能的改变相关,突出显示了体重管理在MS护理中的重要性.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 肥胖会加剧多发性硬化症 (MS) 疾病的活动.
- 心理生物学压力处理是与炎症相关的重要肥胖因素.
- 与MS相关的肥胖症中压力处理的作用尚不清楚.
研究的目的:
- 研究体质指数 (BMI),神经压力处理 (功能连接,FC) 和MS患者的免疫激素压力参数之间的关系.
- 探索BMI,大脑活动和MS中压力反应途径之间的相互作用.
主要方法:
- 在57名患有多发性硬化症的人群中,利用动脉脊柱标记MRI评估神经应激处理 (FC) 在休息和压力条件下.
- 测量了唾液皮质醇和T细胞葡萄糖皮质体 (GC) 敏感度.
- 使用定量PCR分析T细胞中的基因表达 (例如,FKBP4,FKBP5).
主要成果:
- 较高的BMI与增加的MS疾病活性 (复发率) 有关.
- 在休息时,BMI与右上边缘回形和前面的岛屿中的FC正相关.
- 在压力期间,BMI与右上顶顶叶片和小脑中的FC负相关.
- 较高的BMI与改变的T细胞GC敏感性有关,特别是较低的CD8+ FKBP4和较高的CD8+ FKBP5表达.
- CD8+ FKBP4表达在休息期间与右侧上边脊椎和左上顶顶叶片中的FC正相关.
结论:
- 身体质量与MS患者的神经激素压力处理相互联系.
- 观察到的关联表明神经,激素和人体质量调节网络之间的重叠.
- 了解这种多系统交叉通话对于管理MS肥胖症至关重要.
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