前半岛和其投射到杏仁核调节了禁欲加剧的条件化位置偏好表达

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Andrés Agoitia¹, Apolinar Cruz-Sanchez¹, Israela Balderas¹

¹División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico.

Psychopharmacology

|November 27, 2023

概括

前部岛内皮层 (aIC) 和它的投射对于戒断期间增加药物渴望至关重要. 这个大脑区域驱动暗示诱导的寻找药物,特别是在长时间的戒断后.

科学领域:

神经科学是一个神经科学.
成研究研究成研究
行为药理学行为药理学

背景情况:

吸毒复发通常是由与毒品有关的环境线索引发的.
吸毒渴望的潜伏期描述了随着更长的戒断期而增加的寻求毒品的增加.
岛内皮质在物质使用障碍和暗示诱导的寻找毒品方面发挥着作用.

研究的目的:

为了研究前岛皮层 (aIC) 和其对杏仁核 (aIC-AMY) 的谷氨基基投射在早期和晚期戒断期间的条件位置偏好 (CPP) 表达中的作用.
为了确定aIC-AMY途径是否影响药物渴望的潜伏期.

主要方法:

在雄性C57BL/6J小鼠中确立了胺诱导的CPP.
在1天 (早期戒断) 和14天 (晚期戒断) 后评估了CPP表达.
在aIC和aIC-AMY中使用光遗传沉默和NMDA受体对抗来评估功能作用.

主要成果:

经过14天的戒断,与1天相比,观察到对安非他命配对环境的偏好明显加剧.
对aIC或aIC-AMY投影的光遗传抑制仅在晚期戒断期间降低了CPP表达.
在14天后,aIC NMDA受体的对抗性也降低了CPP表达,但在禁欲1天后没有降低.

结论:

在戒断期间,aIC及其对桃体的谷氨基基输出对于对药物线索的增强动机反应至关重要.
这些发现表明,aIC-AMY途径在药物渴望的潜伏中调解了增强的暗示反应性.
在禁欲期间皮质NMDA受体信号敏感化可能会导致不成比例的药物寻找.

关键词:

禁欲禁欲禁欲禁欲禁欲氨基胺是一种安非他命.阿米格达拉的一个桃体.前部岛屿皮层的前部岛屿皮层有条件的地方偏好.激励的突出性突出性吸毒渴望的潜伏期吸毒渴望的潜伏期奖励的上下文记忆是有价值的

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