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[在莫斯科患者的结直肠癌中致病性生殖系变异的结构]

A B Semenova1, M M Byakhova1, M V Makarova2

  • 1City clinical oncology hospital No. 1, Moscow, Russia.

Arkhiv patologii
|November 27, 2023
PubMed
概括

在17.2%的莫斯科结直肠癌患者中发现了致病性生殖系变异,林奇综合征和家族腺瘤多重症是常见的. 这些突变与较早的癌症发病和更高的癌症程度有关,但并没有增加转移.

关键词:
林奇综合征是什么? 林奇综合征是什么?桑格尔测序是什么意思这是一种家族性腺瘤多重症.遗传性癌症综合征 遗传性癌症综合征遗传性结直肠癌 是一种遗传性结直肠癌.下一代测序的下一代测序.整个基因组的测序.

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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