富含甘油三蛋白的脂质蛋白的脂质组,来源于炎症的高脂血症患者
Juan Moreno-Vedia1, Dídac Llop1,2, Ricardo Rodríguez-Calvo1,2
1Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Universitat Rovira i Virgili. Institut Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain.
European journal of clinical investigation
|November 27, 2023
概括
高水平的富含三糖蛋白脂蛋白 (TRL) 与炎症增加相关. 富含胆固醇和脂的TRL颗粒是炎症反应的更强的诱导剂,有助于动脉样硬化发展.
科学领域:
- 心血管研究的心血管研究.
- 脂质新陈代谢 脂质新陈代谢
- 炎症生物学 炎症生物学
背景情况:
- 富含三糖蛋白脂蛋白 (TRLs) 因其大小和内皮透而与动脉样硬化有关.
- 在代谢性疾病中,TRLs和特定的TG衍生代谢物驱动炎症的动脉毒性潜力仍然不清楚.
研究的目的:
- 从高脂血症患者的TG丰富的TRL中调查脂质组修饰.
- 评估这些变化与体内/体外炎症状态之间的关联.
主要方法:
- 质子核磁共振 (1H-NMR) 对307名失脂症患者的血糖蛋白乙和TRL脂类药物的分析.
- 使用THP-1巨细胞进行体外研究,以评估TRL介导的炎症影响.
主要成果:
- 较高的TRL-TG水平与循环中的葡萄糖蛋白 (Glyc-A,Glyc-B,Glyc-F) 的增加相关.
- TRL-TG丰富改变了脂质组成,降低了胆固醇/脂和和脂肪酸,同时增加了欧米茄-9脂肪酸.
- 在体外,TRL增加了IL-1β和TNF-α的分泌;富含胆固醇/脂的TRL更强效,激活了MAPK,Akt/NFκB和caspase-1通路.
结论:
- 升高的TRL-TG水平与系统性炎症的增加和TRL颗粒度的增加有关.
- 在体外,较高的TRL颗粒度促进了促炎性细胞因子分泌,富含胆固醇和脂的TRL表现出更大的促炎活性.
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