对于Benzodiazepine止痛量表的预期初步验证
Emma C Lape1, Jessica M Powers2, Lisa R LaRowe3
1Department of Psychology, Syracuse University.
Experimental and clinical psychopharmacology
|November 27, 2023
概括
患有慢性疼痛的人经常使用二类药物 (BZD) 缓解疼痛,冒着依赖的风险. 一个新的尺度显示BZD止痛期望与疼痛和危险的阿片类药物使用有关,这表明了治疗目标.
科学领域:
- 心理学 心理学 心理学
- 临床心理学 临床心理学
- 疼痛管理 疼痛管理
背景情况:
- 慢性疼痛患者有较高的二二胺 (BZD) 处方率和滥用风险.
- 用BZD来缓解疼痛可能会导致使用升级,并与处方阿片类药物同时发生.
- 认知因素,如期望,对于理解疼痛-BZD关系至关重要.
研究的目的:
- 为了验证新的"对二胺止痛药 (EBA) 的预期"尺度.
- 探索EBA得分与处方阿片类药物使用行为之间的联系.
- 在慢性疼痛患者中调查BZD止痛药的预期.
主要方法:
- 调整并验证了对二胺止痛药 (EBA) 的预期量表.
- 调查了306名患有慢性疼痛的成年人和目前的BZD处方.
- 分析了心理测量特性和与疼痛的相关性,BZD滥用和阿片类药物使用.
主要成果:
- 欧洲银行评级表显示出良好的心理测量有效性,包括单因素结构和高内部一致性 (α = .93).
- EBA评分与疼痛严重程度,BZD滥用可能性,依赖症状和自我报告的止痛使用相关.
- 在处方阿片类药物患者中,较高的EBA得分与较高风险的阿片类药物使用行为有关.
结论:
- 对于长期疼痛患者来说,二胺止痛药的预期是一种有效的构造.
- 这些期望与疼痛,BZD滥用和危险的阿片类药物使用有关.
- 预期的BZD镇痛剂代表了对伴随性疼痛和BZD使用的潜在治疗目标.
相关概念视频
Anxiolytic Drugs: Benzodiazepines and Buspirone
798
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
798
Stages of General Anesthesia
458
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
458
Anxiolytic Drugs: Overview
325
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
325
Sedatives and Hypnotics Drugs: Benzodiazepines
265
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
265
The Placebo Effect
6.2K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.2K
Blind Procedures
10.6K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K


