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裂唇/裂的起源的母性因素:一个基于人口的病例控制研究
Lili Ács1, Bálint Nemes1, Krisztián Nagy2,3
1Department of Paediatric Dentistry and Orthodontics, Semmelweis University Faculty of Dentistry, Budapest, Hungary.
Orthodontics & craniofacial research
|November 27, 2023
概括
怀孕早期的贫血,吐和感染等母亲的健康问题显著增加了口腔口腔裂的风险,包括带有或没有口腔裂的裂唇 (CL±CP). 生活方式因素也在这些常见的出生缺陷中起作用.
科学领域:
- 医学研究 医学研究
- 遗传学和发育生物学
- 公共卫生 公共卫生
背景情况:
- 耳面裂是一种常见的先天性异常,在全球范围内,每1000例活产儿中约有1.5-1.7例发生.
- 带有或没有裂的口唇裂 (CL±CP) 是 orofacial 裂最常见的形式.
- 导致CL±CP的确切环境和母性因素在很大程度上仍未确定.
研究的目的:
- 调查与CL±CP发展相关的潜在的孕产妇风险因素.
- 分析怀孕第一季度社会人口统计学,医疗和生活方式因素的影响.
主要方法:
- 一个用匈牙利先天性异常病例控制监测数据进行的病例控制研究.
- 包括1648个CL±CP病例,2654个匹配的对照和57231个人口对照.
- 多变量条件逻辑回归分析用于估计各种母因子的调整几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 母亲贫血,过度吐和威胁堕胎与更高的CL±CP风险有关.
- 观察到母亲流感 (OR:2.4),急性支气管炎 (OR:4.5),尿路感染 (OR:3.5) 的风险增加.
- 与对照人群相比,母体偏头痛和基本高血压的患病率更高;不熟练的母体就业也是一个重要因素.
结论:
- 孕妇的健康状况和第一季度的生活方式选择是CL±CP发展的重要因素.
- 怀孕早期的孕产妇疾病和某些社会人口因素是可识别的风险因素或面部裂.
- 对这些因素的进一步研究可以为CL±CP的预防策略提供信息.
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