各种病毒感染与多发性硬化症之间的关联:系统性审查和元分析的总体综述
Arash Bakhshi1, Narges Eslami2, Naeim Norouzi2
1Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Reviews in medical virology
|November 27, 2023
概括
这项研究发现,SARS-CoV-2和爱斯坦-巴尔病毒 (EBV) 显著增加了多发性硬化症 (MS) 的风险. SARS-CoV-2显示出比EBV更强烈的关联,挑战了关于MS病变的先前假设.
科学领域:
- 神经免疫学 神经免疫学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种具有复杂病因的免疫媒介脱髓化疾病.
- 环境因素,遗传学和感染都与MS的发病有关.
- 特定病毒感染在MS发展中的作用需要进一步澄清.
研究的目的:
- 进行一项综合性审查,评估各种病原体与多发性硬化症 (MS) 之间的关联.
- 根据相互矛盾的证据,专门调查SARS-CoV-2和爱斯坦-巴尔病毒 (EBV) 对MS风险的影响.
- 综合来自多个关于MS病毒关联的元分析的发现.
主要方法:
- 从Scopus,PubMed和Web of Science数据库系统地收集和分析元分析,直到2023年5月.
- 使用评估系统性审查的方法质量2和GRADE标准进行评估的方法质量.
- 使用综合元分析进行的统计分析,置信区间为95%和p < 0.05的显著性水平.
主要成果:
- 评估了12种病毒与MS的相关性.
- SARS-CoV-2 显示出与多发性硬化症最强的负相关性 (几率比: 3.74).
- 爱斯坦-巴尔病毒 (EBV) (OR: 3.33),人类疹病毒6 (HHV-6) (OR: 2.81),简单疹病毒2 (HSV-2) (OR: 1.76) 和疹病毒 (VZV) (OR: 1.72) 也显示出与MS的显著负面关系.
结论:
- 最近的流行病学数据表明,SARS-CoV-2可能比以前认为的对MS产生更大的影响,这挑战了EBV的既定作用.
- 多发病毒感染与患多发性硬化症的风险增加有显著关联.
- 需要进一步的研究,以阐明这些病毒对多发性硬化症病原有助的确切机制.
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