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在创伤性脑损伤的成年人中,白质完整性和姿势控制之间的关联

Cris Zampieri¹, Jacob B Leary¹, Pashtun Shahim¹

¹Rehabilitation Medicine Department, National Institutes of Health, Bethesda, Maryland, United States of America.

|November 27, 2023

概括

创伤性脑损伤 (TBI) 破坏了白质的完整性,影响了平衡控制. 这项研究将特定的白质通道与TBI成年人的感官组织测试和稳定性测试的极限相联系,以平衡通过感官组织测试和稳定性测试测量的缺陷.

科学领域:

神经科学是一个神经科学.
神经学神经学
生物力学生物力学

背景情况:

在创伤性脑损伤 (TBI) 后,异常的姿势摆动是常见的.
与TBI相关的平衡问题的神经支需要进一步调查.
在儿科TBI中之前的研究表明平衡测试和白质完整性之间的联系.

研究的目的:

在儿童中复制有关感官组织测试 (SOT) 性能和TBI成年人的WM完整性的发现.
探索扩散张力成像 (DTI) 测量WM完整性和TBI成年人的稳定性极限 (LOS) 测试之间的关系.
确定受TBI影响的特定WM路径,与余额赤字相关.

主要方法:

扩散张力成像 (DTI) 用于评估白质 (WM) 完整性.
评估了56名有TBI病史的成年参与者.
通过感官组织测试 (SOT) 和稳定性极限 (LOS) 测试来评估平衡.

主要成果:

证实了SOT表现和WM完整性之间的关系,在中介的lemniscus和中脑小脚.
确定了SOT和后部体辐射之间的新关联.
发现异常的LOS分数和多个通道的WM完整性受损之间存在显著的相关性,包括带膜,体和皮质脊髓通道.

结论:

创伤性脑损伤通过白质完整性的广泛破坏影响平衡.
多个白质道涉及到在TBI后保持姿势控制.
研究结果强调了TBI对感觉运动一体化和平衡的广泛神经影响.

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Traumatic Brain Injury l: Introduction

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