炎症标志物对缺血性中风患者功能结果的预测值
Fariborz Rezaeitalab1, Maryam Esmaeili1, Amin Saberi2
1Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Current journal of neurology
|November 27, 2023
概括
像TNF-α,IL-6,IL-1β和hsCRP这样的炎症标志物不能可靠地预测患有不太严重的缺血性中风的患者的结果. 这项研究发现,这些标志物与患者预后之间没有显著的关联.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 炎症过程与缺血性中风的病理生理学有关.
- 调查特定的炎症标志物如TNF-α,IL-6,IL-1β和hsCRP与中风结局有关的关键是至关重要的.
研究的目的:
- 评估瘤亡因子-α (TNF-α),干白素6 (IL-6),IL1β (IL-1β) 和高灵敏性C反应蛋白 (hsCRP) 水平之间的关系,以及较不严重的缺血性中风患者的预后.
- 为了确定这些炎症标志物是否可以预测急性缺血性中风 (AIS) 患者的功能结果.
主要方法:
- 在中风后的第1天和第5天使用ELISA测量IL-1β,IL-6,hsCRP和TNF-α水平.
- 在CT/MRI上使用ASPECTS和pcASPECTS评估心脏病发作体积.
- 在基线,第5天和第3个月使用NIHSS和MRS评估中风严重程度和功能结果.
主要成果:
- 在良好和不良结局组之间没有观察到炎症标志物水平的显著差异 (P > 0.05).
- 炎症标志物与心脏病发作量没有显著关联 (ASPECTS,pcASPECTS).
- 在炎症标志物与NIHSS和MRS随时间变化之间没有发现显著的相关性.
结论:
- hsCRP,IL-1β,IL-6和TNF-α的水平不是在患有不严重急性缺血性中风的患者中功能性结果的可靠预测指标.
- 可能需要进一步的研究来确定可靠的预后生物标志物来确定较不严重的AIS.
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