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水管和香烟的吸烟以及药物和酒精的消费,以及初级渐进性多发性硬化症的风险:基于人口的病例控制研究
Seyyed Hosein Mortazavi1, Abdorreza Naser Moghadasi1, Amir Almasi-Hashiani2,3
1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Current journal of neurology
|November 27, 2023
概括
吸烟和被动烟雾暴露是原发性渐进性多发性硬化症 (PPMS) 的重要危险因素. 多种烟草制品的联合使用进一步增加了PPMS的风险,突出了吸烟预防计划的必要性.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 环境健康 环境健康
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统疾病.
- 初级渐进性多发性硬化症 (PPMS) 是一种主要的MS亚型,具有未知的环境风险因素.
- 调查可修改的风险因素,如吸烟,对于预防PPMS至关重要.
研究的目的:
- 确定吸烟,吸烟,药物滥用,酒精消费和发展PPMS的风险之间的联系.
- 确定有助于PPMS发展的特定环境风险因素.
主要方法:
- 在伊朗德黑兰进行的一项基于人口的病例控制研究.
- 包括146个PPMS病例和294个性别匹配的健康对照.
- 逻辑回归分析用于计算各种风险的赔率比率 (OR).
主要成果:
- 吸烟 (OR=2.48) 和被动吸烟 (OR=2.20) 与增加PPMS风险显著相关.
- 水管吸烟与PPMS风险没有显著关联 (OR=1.19).
- 使用所有三种类型的吸烟 (水管,香烟,被动) 个体的风险要高得多 (OR=10.45).
结论:
- 吸烟和暴露在被动烟雾中被确定为PPMS的重要危险因素.
- 多种吸烟类型的累积效应放大了PPMS风险.
- 调查结果强调了公共卫生干预措施的重要性,以减少烟草使用,以预防PPMS.
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