初级渐进性多发性硬化症的病史风险因素:一个病例对照研究
Hossein Maroufi1, Abdorreza Naser Moghadasi1, Hossein Rezaei-Aliabadi2
1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Current journal of neurology
|November 27, 2023
概括
抑郁症,传染性单核病,甲状腺功能低下和功能衰竭的病史可能会增加患初级渐进性多发性硬化症 (PPMS) 的风险. 然而,偏头痛史似乎降低了PPMS风险.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 医学史 医学史 医学史
背景情况:
- 过去的疾病和初级渐进性多发性硬化症 (PPMS) 之间的联系尚未得到充分证实.
- 这项研究调查了23种特定疾病与PPMS发生之间的关联.
研究的目的:
- 评估各种病史和PPMS发展之间的潜在关系.
- 确定可能影响PPMS风险的特定条件.
主要方法:
- 在伊朗德黑兰 (2019-2020) 进行的一项基于人口的病例控制研究.
- 包括使用2017年麦当劳标准诊断的143例PPMS病例和143个性别匹配的健康对照.
- 通过采访收集的数据;使用条件后勤回归来确定赔率比率 (OR) 和95%置信区间 (CI) 的统计分析.
主要成果:
- 在PPMS和抑郁症 (OR=3.12),传染性单核病 (OR=13.16),甲状腺功能低下 (OR=3.20) 和功能衰竭 (OR=3.76) 之间发现了显著的关联.
- 偏头痛病史显示与PPMS有显著的反向关联 (OR=0.19).
结论:
- 在一生中患有抑郁症,传染性单核病,甲状腺功能低下和功能衰竭的病史可能会增加PPMS的风险.
- 患有偏头痛病史的人可能患PPMS的风险降低.
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