维生素D的使用是否对急性缺血性中风患者的结果有影响? 一个随机对照试验
Omidvar Rezaei1, Mahtab Ramezani1, Mehrdad Roozbeh2
1Skull Base Research Center, Loghman Hakim Hospital Complex, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Current journal of neurology
|November 27, 2023
概括
在急性缺血性中风患者中,单次肌肉注射维生素D补充剂改善了神经功能,降低了IL-6水平. 然而,它没有显著影响TNF-α或NIHSS得分.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 临床研究表明,维生素D补充剂可以改善神经系统的结果.
- 急性缺血性中风 (AIS) 带来了重大的神经挑战.
- 炎症标志物在中风病理生理学中发挥作用.
研究的目的:
- 调查肌内 (IM) 维生素D对AIS患者神经结果的影响.
- 评估IM维生素D对AIS中的炎症标志物 (IL-6,TNF-α) 的影响.
- 为了评估修改后的Rankin尺度 (MRS),NIHSS和MMSE得分的变化,补充后.
主要方法:
- 一个随机对照试验,涉及60名AIS患者.
- 干预组接受了一次300000 IU IM维生素D剂量;对照组没有.
- 主要结局:血清维生素D,IL-6,TNF-α. 二次结局:MRS,NIHSS,MMSE,在基线和6周测量.
主要成果:
- 补充后,维生素D水平显著增加.
- 观察到MRS和IL-6水平有所改善 (P=0.01,P=0.02).
- 在维生素D和NIHSS/TNF-α之间发现了反向相关性,但对于TNF-α,NIHSS或MMSE没有显著的群体差异.
结论:
- 一次IM剂量维生素D在AIS患者中改善了MRS和IL-6.
- 没有观察到对TNF-α或NIHSS得分的显著有利影响.
- 限制包括单剂量,短时间和随访期,可能限制更广泛的影响.
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