螺旋杆菌与多发性硬化症的关联:保护因素还是危险因素?
Omid Mirmosayyeb1,2, Mahdi Barzegar1,2, Nasim Nehzat1,2
1Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
这项研究发现,Helicobacter pylori (HP) 感染和渐进性多发性硬化症 (MS) 之间存在显著的关联. 需要进一步的研究来确认HP在MS发展和进展中的作用.
科学领域:
- 神经免疫学 神经免疫学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种自身免疫性中枢神经系统炎症性疾病,病因不明.
- 环境因素,包括感染,都与MS的发病有关.
- 之前对Helicobacter pylori (HP) 和MS的研究已经产生了相互矛盾的结果.
研究的目的:
- 调查与健康对照组相比,各种形式的多发性硬化症患者中HP感染的频率.
- 探索HP感染和MS临床特征之间的潜在关联.
主要方法:
- 这是一项涉及2015-2019年191名参与者 (CIS,RRMS,SPMS和HC) 的横截面研究.
- 血清样本进行了Helicobacter pylori免疫球蛋白G (IgG) 和IgM抗体的测试.
- 统计分析包括单变量和多变量模型来评估关联.
主要成果:
- 与CIS,RRMS和健康对照组 (HCs) 相比,二次进展性MS (SPMS) 患者的HP IgG血清阳性显著更高.
- 在单变量和多变量分析中,SPMS被确定为HP IgG血清阳性的预测因子.
- 在研究组中没有观察到HP IgM血清阳性方面的显著差异.
结论:
- 渐进式的多发性硬化症,特别是SPMS,显示出与HP感染的潜在关联.
- 进一步进行大规模的纵向研究是有必要的,以阐明HP感染在MS病因和进展中的作用.
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