患有急性缺血性中风的男性的和雌激素:一个北印度的病例控制
Jayeeta Bhadra1, Shashi Seth2, Manishraj Kulshrestha3
1Vallabhbhai Patel Chest Institute, Delhi University, New Delhi, India.
Current journal of neurology
|November 27, 2023
概括
低丸激素水平与男性急性缺血性中风 (AIS) 的更糟糕结果有关. 较低的丸激素与较高的中风严重程度和较大的心脏病发作大小相关,这表明丸激素在中风中的潜在作用.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 心血管研究研究心血管研究
背景情况:
- 男性中风发病率高于女性,可能是由于性激素.
- 和雌激素是关键的内源性激素,与基于性别的中风差异有关.
研究的目的:
- 为了研究急性缺血性中风 (AIS) 的男性的血清丸激素和雌激素水平.
- 在CT扫描上将激素水平与中风严重程度 (NIHSS得分) 和心脏病大小相关联.
主要方法:
- 一个病例控制研究,涉及100名男性AIS患者和100名年龄相匹配的对照.
- 排除标准包括出血性中风,激素治疗和慢性疾病.
- 评估包括NIHSS用于严重程度,CT用于心脏病发作大小,以及血清激素水平量化.
主要成果:
- 与对照组 (515.34 ng/dl) 相比,AIS患者的平均总水平显著降低 (223.30 ng/dl).
- 雌醇水平在两组之间没有显著差异.
- 在总和中风严重程度 (r = -0.581) 和心脏病发作大小 (r = -0.557) 之间观察到显著的逆相关性.
结论:
- 低血清丸激素水平与AIS男性中风严重程度和心脏病大小的增加有关.
- 需要进一步的研究来确定低丸激素是否是AIS的原因或影响,并探索丸激素补充的好处.
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