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在健康人群中,血清25-基维生素D水平与亚临床动脉样硬化之间的关联

Vida Mohammadzadeh^1,2, Masoud Mehrpour^3,4, Abdoreza Ghoreishi^1,2

¹Department of Neurology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Current journal of neurology

|November 27, 2023

概括

维生素D水平较低与亚临床动脉样硬化有关,由心动脉内心介质厚度 (CIMT) 的增加表明. 这项研究发现,在没有心血管风险因素的个体中,血清25-基维生素D3水平较低和CIMT水平较高之间存在显著的关联.

科学领域:

心血管科学心血管科学
内分泌学在内分泌学.
公共卫生公共卫生

背景情况:

亚临床动脉样硬化,心动脉动脉样硬化的无症状阶段,对于预防脑血管疾病至关重要.
维生素D在血管健康中的作用是公认的,但其与亚临床动脉样硬化症的关联需要进一步研究.
早期发现亚临床动脉样硬化对于及时干预和预防疾病至关重要.

研究的目的:

为了研究血清维生素D水平与动脉内心介质厚度 (CIMT) 之间的关联.
在伊朗人群中探索血清25-基维生素D3 [25(OH) D3]和CIMT之间的关系.
评估与维生素D状况相关的亚临床动脉样硬化的患病率.

主要方法:

分析了一组100名年龄在20-50岁之间,没有心血管风险因素的个人.
测量了血清中25-氧维生素D3 [25(OH) D3] 度和动脉内心介质厚度 (CIMT).
包括糖尿病,高血压,吸烟,失脂症和药物史在内的混因素被排除在外.

主要成果:

55%的受试者表现出亚临床动脉样硬化 (IMT ≥0.75毫米).
与整体平均值 (0.74 ± 0.12 mm) 相比,严重维生素D缺乏组的IMT平均值更高 (0.86 ± 0.30 mm).
在血清25(OH) D3水平和CIMT (P = 0.002) 之间发现了显著的关联,并观察到反向相关性.

结论:

在没有心血管风险因素的个体中,血清25(OH) D3水平与CIMT相反相关.
在患有亚临床动脉样硬化症的参与者中,严重的维生素D缺乏更为普遍.
这些发现表明,维生素D在早期动脉样硬化的发展或进展中可能发挥作用.

关键词:

动脉样硬化是一种动脉样硬化.冠状动脉内心介质的厚度维生素D 维生素D是一种维生素.

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