维生素B及其组合可以减少偏头痛:一项随机双盲对照试验
Shiva Nematgorgani1,2, Soodeh Razeghi-Jahromi1,2, Elham Jafari3
1Department of Clinical Nutrition and Dietetics, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Current journal of neurology
|November 27, 2023
概括
补充B族维生素 (B1,B6,B12,B9) 显著降低了发作性偏头痛的女性的头痛频率和残疾. 这种B族维生素治疗也减少了急性偏头痛药物的需要.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 临床试验 临床试验
背景情况:
- 插曲性偏头痛 (EM) 是一种流行的神经疾病.
- 维生素B,包括胺 (B1),氧化 (B6),胺 (B12),叶酸 (B9),正在研究它们在偏头痛中的潜在预防作用.
研究的目的:
- 评估单个和联合B族维生素补充剂在治疗女性间歇性偏头痛方面的疗效.
- 评估维生素B补充剂对头痛频率,残疾和药物使用的影响.
主要方法:
- 这是一项双盲,安慰剂控制,随机的临床试验,涉及120名患有偶发性偏头痛的女性.
- 参与者被分配到六个组之一:B1,B6,B12,B9,维生素B复合物或安慰剂,每天服用一粒囊,持续12周.
- 头痛日记和偏头痛残疾评估问卷 (MIDAS) 用于数据收集.
主要成果:
- 与安慰剂相比,所有维生素B组的头痛发作频率显著降低 (P < 0.001).
- 所有维生素组的偏头痛残疾分数与安慰剂相比显著改善 (P < 0.001).
- 用维生素B补充剂导致堕胎药物的消费显著减少 (P = 0.032).
结论:
- 单独或组合使用的胺 (B1),氧化 (B6),胺 (B12),叶酸 (B9) 均显示出作为偶发性偏头痛辅助疗法的潜力.
- 需要进一步的大规模,长期的研究来证实这些发现,并建立最佳的治疗方案.
相关概念视频
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
285
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
285
01:30Vitamins
732
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
732
01:23Antidepressant Drugs: MAOIs and Other Agents
248
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
248
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
215
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
215