使用基于可光治愈的氨酸的生物降解密封剂增强持续修复
Hyeseon Lee1, Sijoon Lee2, Keum-Yong Seong1
1Department of Biomaterials Science (BK21 Four Program), Life and Industry Convergence Institute, Pusan National University, Miryang, 50463, Republic of Korea.
Macromolecular bioscience
|November 27, 2023
概括
一种新型的光激活氨酸密封剂为神经外科手术提供了快速,防水的持续闭合. 这种生物相容的HA光剂加速了持续的修复和骨形成,在没有任何不良影响的情况下超过商业合剂.
科学领域:
- 生物材料科学 生物材料科学
- 神经外科 神经外科
- 组织工程是组织工程.
背景情况:
- 脑脊液 (CSF) 泄漏是一种常见的神经外科并发症.
- 传统的长期接是耗时的,容易导致不完全的密封.
- 现有的密封剂在密封性能,生物相容性和膨胀方面存在局限性.
研究的目的:
- 开发和评估一种基于光激活氨酸 (HA) 的新型耐用密封剂.
- 评估HA光隔热剂对持续修复的有效性和生物相容性.
- 在临床前模型中,将HA光剂与商业手术粘合剂进行比较.
主要方法:
- 开发一种通过可见光 (405 nm,<1 J cm−2) 激活的多网络HA光隔热剂.
- 在湿的耐用表面上对密封性能和组织粘附的评估.
- 在骨切除和长度切除的子模型中进行临床前研究,将HA光隔离剂与商业合剂进行比较.
- 组织病理学评估炎症,亡和骨形成.
主要成果:
- 在5秒内,HA光隔热剂迅速形成一个防水的水凝屏障.
- 它表现出坚固的粘附于潮湿的耐用表面.
- 在子中,与商业合剂相比,HA光剂实现了更快的持续撕裂密封,并提高了与加速骨形成的持续修复.
- 没有观察到炎症或亡等退行性变化.
结论:
- 开发的HA光密封剂提供快速,防水,持久的关闭,具有高生物相容性.
- 与现有的手术粘合剂相比,它在密封持续撕裂和促进持续修复方面表现出卓越的性能.
- 这种HA光剂对各种需要在神经外科手术中快速关闭伤口的临床应用具有前景.
更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
11.9K
06:05Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
Published on: July 14, 2023
1.0K
相关概念视频
00:46Bioremediation
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
01:54Base Excision Repair
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
The first step of...
01:02Long-patch Base Excision Repair
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
01:27Chemical Agents for Microbial Control
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
01:28Microbial Bioremediation of Pesticides
Pesticides often feature structurally complex chemical architectures, incorporating halogen groups and multiple aromatic rings. These characteristics confer high chemical stability, rendering many pesticides resistant to natural degradation processes. This resistance poses significant environmental concerns, as persistent pesticide residues can accumulate in ecosystems and affect non-target organisms.Despite the inherent stability of many pesticides, certain microorganisms possess the metabolic...
01:28Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...