红细胞瘤是罕见的与外源性在性别确认激素治疗中的异源性丸激素
Nithya Krishnamurthy1, Daniel J Slack2, Moira Kyweluk3
1Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.
The Journal of clinical endocrinology and metabolism
|November 27, 2023
概括
对性别肯定 (GAHT) 的丸激素治疗显示出血红素的统计学显著变化,但绝对水平保持在正常范围内,红细胞瘤患病率低. 这些研究结果表明,甲对血红素水平来说是安全的.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 跨性别者健康 跨性别者健康
背景情况:
- 红细胞瘤发生率在接受性别肯定激素治疗 (GAHT) 与的个体中有所不同.
- 了解对血红素的影响对于安全的GAHT协议至关重要.
研究的目的:
- 为了研究外源在GAHT对血红素水平的影响.
- 在一个大型的北美队列中,根据丸激素值和给药途径分析血红素值变化.
主要方法:
- 从6670名患者的实验室值进行横截面分析,这些患者通过Plume处方丸激素.
- 评估红细胞瘤发病率,不同水平的平均血红素值,以及给药途径 (肌内 vs 透皮).
主要成果:
- 8.4%的个体具有血红素≥50%.
- 观察到与不同丸激素值 (P < .001) 相关的显著血位变化.
- 肌内丸激素与通过皮肤的平均血红素比通过皮肤的平均血红素更高 (44.96%与43.41%,P <.001).
结论:
- 统计学上显著的血红素变化与丸激素水平和给药途径.
- 绝对血红素水平通常在正常范围内,这表明临床意义较低.
- 红细胞瘤的低患病率支持丸激素在GAHT中使用的安全性.
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