LncPCD:手工策划的数据库,实验支持了 lncRNA介导的编程细胞死亡与疾病之间的关联
Ni He, Danyang Li1, Fanfan Xu1
1Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Baojian Road, Nangang District, Harbin, Heilongjiang 150081, China.
Database : the journal of biological databases and curation
|November 27, 2023
概括
一个新的数据库,LncPCD,列出了各种疾病中长非编码RNA (lncRNA) 和编程细胞死亡 (PCD) 之间的关联. 此资源有助于研究 lncRNA 功能和疾病进展的机制.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 疾病机制 疾病机制
背景情况:
- 编程细胞死亡 (PCD) 对于保持内部稳定性至关重要.
- 长非编码RNAs (lncRNAs) 在疾病的PCD进展中起着重要作用.
- 对lncRNA-PCD-疾病关联缺乏一个专门的存储库.
研究的目的:
- 开发LncPCD,为实验支持的lncRNA介导PCD和疾病关联提供全面的数据库.
- 整合有关lncRNA调控机制,相关细胞类型,亚细胞位置和临床应用的信息.
主要方法:
- 关于 lncRNA-PCD-疾病关联的文献手册.
- 整合单细胞测序数据集以分析 lncRNA 动态.
- 开发一个网络可访问的数据库 (LncPCD).
主要成果:
- LncPCD数据库记录了6666个关联,涉及331种疾病和五种PCD类型的1222个lncRNA.
- 包含了关于7个lncRNA调节机制,310种PCD相关细胞类型,lncRNA位置和临床应用的详细信息.
- 整合了10个单细胞测序数据集,用于动态 lncRNA 分析.
结论:
- 对于研究疾病中 lncRNA介导的 PCD 的研究人员来说,LncPCD 是一个宝贵的资源.
- 该数据库有助于更深入地了解 lncRNA 功能和疾病机制.
- 它支持与lncRNA-PCD相互作用相关的临床应用的探索.
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