全球,区域和国家的不孕症负担归因于PCOS,1990-2019年
Xingyu Liu1,2,3, Jinjin Zhang1,2,3, Shixuan Wang1,2,3
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Human reproduction (Oxford, England)
|November 27, 2023
概括
由于多囊卵巢综合征 (PCOS) 的不孕症的全球负担在1990年至2019年期间翻了一番,突显了对有效干预的迫切需要. 建议进行体重管理,以减轻这种日益严重的健康问题.
科学领域:
- 生殖健康流行病学 生殖健康流行病学
- 内分泌学 在内分泌学.
- 全球健康 全球健康
背景情况:
- 多囊卵巢综合征 (PCOS) 是无排卵不育的主要原因,影响高达80%的受影响女性.
- 此前,缺乏全面的全球流行病学数据,以年龄和社会人口指数 (SDI) 分层的PCOS归因于不孕不育.
研究的目的:
- 量化可归因于PCOS的全球,区域和国家不孕症负担.
- 从1990年到2019年分析患病率和残疾人生活年数 (YLD) 的趋势.
- 检查PCOS不孕症负担与SDI之间的关联.
主要方法:
- 对15-49岁女性中可归因于PCOS的不孕症的流行率和YLD数据的系统分析.
- 数据来源于2019年全球疾病负担研究.
- 估计按年龄,SDI,地区和国家分层,涵盖1990-2019年期间.
主要成果:
- 在全球范围内,PCOS导致的不孕不育的流行病例从1990年的600万例翻了一番,到2019年的1213万例.
- 年龄标准化流行率和YLD显著增加,在高SDI地区观察到的负担最高.
- 中等和低中等SDI地区的流行率和YLD率的年增幅最大.
结论:
- 可归因于PCOS的不孕症负担在全球显著增加.
- 包括体重控制在内的有针对性的健康干预措施对于管理和减轻这种负担至关重要,特别是在高SDI地区.
- 需要持续收集数据和标准化诊断标准来完善未来的估计.
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