左心变形的优越性在早期与环素相关的心脏功能障碍的检测中
Nhat Giang M1,2, Hai Nguyen H3, Duc Tan Vo4
1Department of Cardiac Intensive Care and Cardiomyopathy, Nhan Dan Gia Dinh Hospital, Ho Chi Minh City, Vietnam minhnhat210189@gmail.com.
Open heart
|November 27, 2023
概括
早期心脏毒性因抗环素化疗是常见的. 左心室全球纵向应变 (LV-GLS) 是检测这种早期癌症治疗相关心脏功能障碍 (CTRCD) 的最佳指标.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 心脏瘤学 - 心脏瘤学
背景情况:
- 人类循环素化疗与心脏毒性有关.
- 早期发现与癌症治疗相关的心脏功能障碍 (CTRCD) 对患者管理至关重要.
- 乳腺癌患者通常具有心血管风险因素,增加了易感性.
研究的目的:
- 为了确定在 antracycline 化疗期间早期 CTRCD 的发生率.
- 在患有CTRCD的患者中表征左和右心脏变形.
- 为了确定最可靠的回声心脏学参数用于早期CTRCD检测.
主要方法:
- 预期招募351名化疗前的乳腺癌患者,这些患者具有心血管风险因素.
- 在多个时间点对左心室喷射分数 (LVEF),左心室全球纵向应变 (LV-GLS) 和右/左心房应变进行心声评估.
- 由LVEF减少或GLS从基线下降来定义的CTRCD.
主要成果:
- 18名患者 (5.1%) 发展出无症状的CTRCD,其中50%发生在化疗完成之前.
- 在CTRCD组中,在第一个人环素剂量后,LV-GLS显著下降.
- 在第二剂后,右心室自由壁纵向应变和左心房储应变的减少被观察到.
结论:
- 心脏毒性可能在人环素治疗的早期表现出来.
- LV-GLS是识别早期CTRCD的最有效的回声心脏学标记.
- 监测LV-GLS可以帮助及时干预抗环素诱导的心脏毒性.
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