低肌肉强度作为不同代谢条件下的非酒精性脂肪肝疾病的危险因素
1Department of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Korean journal of family medicine
|November 27, 2023
概括
低肌肉力量与非酒精性脂肪性肝病 (NAFLD) 的风险更高有关. 这种关联甚至在胰岛素抵抗和代谢综合征的情况下也存在,但与中心肥胖症特别相关.
科学领域:
- 代谢性疾病研究研究.
- 肝脏的健康和疾病.
- 公共卫生和营养
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题.
- 肥胖,胰岛素抵抗和代谢综合征是已知的NAFLD风险因素.
- 低肌肉强度对NAFLD的独立影响需要进一步调查.
研究的目的:
- 为了调查肌肉力量低和NAFLD之间的关联.
- 检查不同代谢条件之间的这种关系,包括胰岛素抵抗,代谢综合征和中心肥胖症.
主要方法:
- 从2019年韩国国家健康和营养检查调查中对5,427名参与者的横截面分析.
- 相对手握强度 (rHGS) 评估肌肉强度,男性和女性的具体切断值.
- 使用肝硬化指数诊断的NAFLD;根据代谢因素进行的亚组分析.
主要成果:
- 低肌肉强度显示在调整混因素后,与NAFLD有显著的关联 (OR,1.92;P<0.001).
- 在胰岛素抵抗,代谢综合征和中心肥胖症的子组中,这种关联仍然显著 (OR,1.66-4.19).
- 在没有中心肥胖症的子组中没有发现显著的关联.
结论:
- 低肌肉强度与NAFLD风险增加独立相关.
- 这种关系独立于胰岛素抵抗和代谢综合征.
- 中部肥胖是调解低肌肉强度和NAFLD之间联系的关键因素.
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