在整个COVID-19大流行期间,青少年的持续性幽默性免疫反应:潜在的基于学校的队列研究
Alessia Raineri1, Thomas Radtke1, Sonja Rueegg1
1Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Hirschengraben 84, 8001 Zürich, Zurich, Switzerland.
Nature communications
|November 27, 2023
概括
大多数儿童和青少年在2022年7月之前开发出了SARS-CoV-2抗尖峰IgG抗体. 混合免疫或疫苗接种显著提高了抗体水平和对抗COVID-19变种的中和能力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 儿童和青少年对SARS-CoV-2的幽默性免疫反应对于公共卫生战略至关重要.
- COVID-19大流行对儿科免疫力的影响,特别是关于Omicron变异的影响,需要详细检查.
研究的目的:
- 从2020年6月到2022年7月,研究学龄儿童和青少年的幽默免疫反应的演变.
- 评估Omicron变种和疫苗接种对这些免疫反应的影响.
主要方法:
- 这项"Ciao Corona"研究涉及1874至2500名参与者,每轮在苏黎世55所学校进行.
- 特别关注的是751名儿童和青少年的纵向队列.
- 在五轮测试中测量了SARS-CoV-2抗尖峰IgG (S-IgG) 抗体和中和反应.
主要成果:
- 到2022年7月,96.9%的参与者已经产生了S-IgG抗体.
- 与未接种疫苗的感染者相比,具有混合免疫或接种疫苗的个人表现出更高的S-IgG标位和更强的中和反应对抗SARS-CoV-2变种 (野生型,三角形,欧米克朗BA.1).
- 在93%的参与者中,S-IgG抗体持续超过18个月.
- 奥米克朗波和疫苗的推出导致S-IgG标位和中和能力的增加.
结论:
- 该研究表明,SARS-CoV-2抗体在儿童和青少年中的患病率很高.
- 疫苗接种和混合免疫显著增强针对COVID-19的幽默性免疫反应.
- 长期持久的S-IgG抗体表明在这个年龄组持续保护.
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