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Updated: Jul 9, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

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在JAK2V617F驱动的骨髓增殖性瘤中,SRSF2突变减少了多细胞血症并损害了造血原体功能

Yue Yang1, Salar Abbas1, Mohammad A Sayem1

  • 1Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.

Blood cancer journal
|November 27, 2023
PubMed
概括

在骨髓增殖性瘤 (MPN) 中,SRSF2突变与JAK2V617F结合,降低血细胞数量和脏大小. 这项研究表明,SRSF2突变会损害造血干细胞的竞争力,但不会导致骨髓纤维化.

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