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Updated: Jul 9, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay

Published on: September 27, 2024

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德乌比奎丁酶USP1增强了CCAAT/增强剂结合蛋白β (C/EBPβ) 的稳定性,并加速了脂肪生成和脂质积累

Myung Sup Kim1,2,3, Jung-Hwan Baek1,2,3, JinAh Lee1

  • 1Department of Biochemistry & Molecular Biology, Seoul, Republic of Korea.

Cell death & disease
|November 27, 2023
PubMed
概括

乌比基特异蛋白酶1 (USP1) 通过控制CCAAT/增强剂结合蛋白β (C/EBPβ) 的稳定性来调节脂肪生成. 用ML323抑制USP1可以减少脂肪积累,并改善饮食诱导的肥胖模型中的代谢健康.

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